New paper out featuring Emyr’s work that connects tuberculosis to NPC1

Published in the first edition of Wellcome Open Research is an article featuring some of the post-doctoral work of Dr. Lloyd-Evans. This article entitled “Pathogenic mycobacteria achieve cellular persistence by inhibiting the Niemann-Pick Type C disease cellular pathway” focuses on the potential role of the NPC1 protein as a target for Mycobacterium tuberculosis, the infectious agent that causes tuberculosis. As one of the leading killers in the under developed world, tuberculosis remains a major human health issue. That the lysosome was involved in tuberculosis was never in question but that a lysosomal disease protein is involved in the process of pathogenicity is an extremely novel finding and highlights new potential therapeutic avenues. Published in this novel journal, with open peer review, it will be interesting to see what people make of the research. We here at the Lloyd-Evans lab would like to pass on our congratulations to all the co-authors involved in the study.

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